Tal1^tm1Wehi
Targeted Allele Detail

Summary

• Symbol: Tal1^tm1Wehi
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:1857566
• Synonyms: scl^-
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^tm1Wehi page

Appearance and histology of Tal1^tm1Wehi/Tal1^tm1Wehi embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27458
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two targeting vectors were used to create two targeted mutations, but these were not distinguished in the paper. Vector 582 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a neomycin gene. Vector 607 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a hygromycin gene. (J:27458)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 33 strains or lines available

References

• Original: J:27458 Robb L, et al., Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7075-9
• All: 7 reference(s)