Hoxc4^tm1Hsu
Targeted Allele Detail

Summary

• Symbol: Hoxc4^tm1Hsu
• Name: homeobox C4; targeted mutation 1, Hirofumi Suemori
• MGI ID: MGI:1857570
• Gene: Hoxc4 Location: Chr15:102927366-102945278 bp, + strand Genetic Position: Chr15, 58.08 cM
• Alliance: Hoxc4^tm1Hsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31635
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 0.6kb of sequence encoding almost all of the homeobox domain. Northern blot analysis did not detect wild-type mRNA transcript in homozygous mutant E12.5 embryos, although an aberrant transcript was detected This raised the possibility that a truncated protein was produced. (J:31635)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc4 Mutation: 9 strains or lines available

References

• Original: J:31635 Saegusa H, et al., Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process. Dev Biol. 1996 Feb 25;174(1):55-64
• All: 1 reference(s)