Runx1^tm1Dow
Targeted Allele Detail

Summary

• Symbol: Runx1^tm1Dow
• Name: runt related transcription factor 1; targeted mutation 1, James R Downing
• MGI ID: MGI:1857580
• Synonyms: AML^-, AML1^-, Runx1^-
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm1Dow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31130
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin B expression cassette replaced the splice acceptor site and the first 20 bp of the exon that encodes the central 52 amino acids of the Runt homology domain (RHD). RT-PCR analysis on RNA derived from whole E11.5 embryos did not detect any transcript in homozygous mice. (J:31130)

Expression

In Mice Carrying this Mutation:	16 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:31130 Okuda T, et al., AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996 Jan 26;84(2):321-30
• All: 11 reference(s)