Smad3^tm1Par
Targeted Allele Detail

Summary

• Symbol: Smad3^tm1Par
• Name: SMAD family member 3; targeted mutation 1, Luis F Parada
• MGI ID: MGI:1857592
• Synonyms: Madh3^-, Smad3^-, Smad3^tm1par-
• Gene: Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
• Alliance: Smad3^tm1Par page

Colon tumor formation and neoplasia in Rab25^tm1Jrgo/Rab25^tm1Jrgo Smad3^tm1Par/Smad3⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49839
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-LacZ-neo cassette was inserted into exon 2 of the gene, truncating the carboxyl-terminal active domain of the protein. In addition, this cassette was inserted in a region where point mutations create loss-of-function proteins. Finally, alternative splicing around the disrupted exon would shift the open reading frame. (J:49839)

Disease models

Expression

In Mice Carrying this Mutation:	116 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad3^tm1Par

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Smad3 Mutation: 22 strains or lines available

References

• Original: J:49839 Zhu Y, et al., Smad3 mutant mice develop metastatic colorectal cancer. Cell. 1998 Sep 18;94(6):703-14
• All: 46 reference(s)