Cbfb^tm1Tok
Targeted Allele Detail

Summary

• Symbol: Cbfb^tm1Tok
• Name: core binding factor beta; targeted mutation 1, Toshihisa Komori
• MGI ID: MGI:1857593
• Synonyms: Cbfb^-
• Gene: Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cbfb^tm1Tok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36250
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic segment containing exon 5. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that only an aberrant transcript which splices exon 4 to exon 6 is produced from this allele. (J:36250)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbfb Mutation: 36 strains or lines available

References

• Original: J:36250 Sasaki K, et al., Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12359-63
• All: 5 reference(s)