Ptk2^tm1Imeg
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1Imeg
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Institute of Molecular Embryology and Genetics
• MGI ID: MGI:1857596
• Synonyms: FAK-
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1Imeg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29273
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into sequences encoding the beginning of the kinase domain. Western blot analysis of lysates derived from E8.5 embryos demonstrated that the protein was absent in homozygotes. (J:29273)

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 91 strains or lines available

References

• Original: J:29273 Ilic D, et al., Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 1995 Oct 12;377(6549):539-44
• All: 14 reference(s)