Cryge^Elo
Spontaneous Allele Detail

Summary

• Symbol: Cryge^Elo
• Name: crystallin, gamma E; eye lens obsolescence
• MGI ID: MGI:1857599
• Synonyms: Cryge^Cat2-Elo, ELO
• Gene: Cryge Location: Chr1:65087713-65090308 bp, - strand Genetic Position: Chr1, 32.8 cM
• Alliance: Cryge^Elo page

Mutation origin

• Strain of Origin: (C57BL/6JNga x Japanese fancy mouse (Oca2^p))F4

Mutation description

• Allele Type: Spontaneous (Dominant negative)
• Mutation: Intragenic deletion
• Mutation details: A single base (G) deletion at nucleotide position 403 (codon 135) in the fourth ""Greek key"" motif of the Cryge gene product, causes a frameshift mutation that can translate for another 11 amino acids before prematurely terminating (codon 146). The truncated peptide lacking the fourth ""Greek key"" probably leads to misfolding of the crystallin gene product and may act as a dominant negative. (J:2144)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cryge Mutation: 25 strains or lines available

References

• Original: J:15383 Oda SI, et al., A new mutation, eye lens obsolescence, Elo, on Chromosome 1 in the mouse. Jpn J Genet. 1980;55:71-5
• All: 7 reference(s)