T^32H
Chemically and radiation induced Allele Detail

Summary

• Symbol: T^32H
• Name: brachyury, T-box transcription factor T; brachyury 32 Harwell
• MGI ID: MGI:1857608
• Synonyms: Del(17)T^32H87H
• Gene: T Location: Chr17:8653255-8661328 bp, + strand Genetic Position: Chr17, 4.92 cM
• Alliance: T^32H page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Chemically and radiation induced
• Mutation: Intergenic deletion
• Mutation details: Analysis of molecular polymorphisms showed the deletion breakpoints of this allele to be distal to D17Leh48 and proximal to Tme, deleting D17Leh119, 66E, T and Qk. (J:62655)
• Inheritance: Semidominant

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	T^32H/T^+ t^h51/t^+	involves: 101/H * C3H/HeH * TFH
cx2	T^32H/T^+ t^w32/t^+	involves: 101/H * C3H/HeH * TFH
cx3	T^32H/T^+ t^6/t^+	involves: 101/H * C3H/HeH * TFH

Phenotypes:

Affected Systems	cx1	cx2	cx3
show or hide all annotated terms
reproductive system	√	√	√
transmission ratio distortion	√	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any T Mutation: 60 strains or lines available

Notes

This allele was recovered among offspring from a (C3H/HeH x 101/H)F1 male treated with triethylenemelamine and 6Gy X rays.

References

• Original: J:50247 Bergstrom RA, et al., Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths. Genetics. 1998 Oct;150(2):815-22
• All: 2 reference(s)