Rara^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Rara^tm1Ipc
• Name: retinoic acid receptor, alpha; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:1857622
• Synonyms: Aalpha, Rara-, RARalpha^-
• Gene: Rara Location: Chr11:98818644-98865768 bp, + strand Genetic Position: Chr11, 62.76 cM, cytoband D-E1
• Alliance: Rara^tm1Ipc page

Degenerative lesions in testes of 4 to 5 month old Rara^tm1Ipc/Rara^tm1Ipc mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:13574
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 8, which encodes the common receptor region B. This disruption is predicted to prevent the synthesis of all Rara isoforms. RNAase protection analysis of homozygous E13.5 embryos failed to detect wild type RNA transcripts and immunoblot analysis failed to detect protein in in extracts from homozygous E13.5 embryos. (J:13574)

Expression

In Mice Carrying this Mutation:	128 assay results
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rara Mutation: 79 strains or lines available

References

• Original: J:13574 Lufkin T, et al., High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9
• All: 32 reference(s)