Apob^tm3Sgy
Targeted Allele Detail

Summary

• Symbol: Apob^tm3Sgy
• Name: apolipoprotein B; targeted mutation 3, Stephen G Young
• MGI ID: MGI:1857625
• Synonyms: apoB-
• Gene: Apob Location: Chr12:8027648-8066835 bp, + strand Genetic Position: Chr12, 3.53 cM
• Alliance: Apob^tm3Sgy page

The yolk sac visceral endoderm from Apob^tm3Sgy/Apob^tm3Sgy embryos contains foamy vacuoles

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23315
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A sequence-insertion vector was used to interrupt the coding sequence after exon 4 and is predicted to result in a truncated protein produced from this allele. (J:23315)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apob Mutation: 224 strains or lines available

Notes

The presence of Tg(APOB)1102Sgy (J:81265) prevented the lethal developmental abnormalities caused by this allele.

References

• Original: J:23315 Farese RV Jr, et al., Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1774-8
• All: 6 reference(s)