Hoxa4^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Hoxa4^tm1Bhr
• Name: homeobox A4; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:1857628
• Synonyms: Hoxa-4-
• Gene: Hoxa4 Location: Chr6:52166662-52168683 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa4^tm1Bhr page

Homeotic transformation of C3 in Hoxa4^tm1Bhr/Hoxa4^tm1Bhr mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22077
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the sequences encoding the first helix of the homeodomain. No mRNA was detected in Northern blots of RNA derived from E12.5 homozygous embryos. (J:22077)

Expression

In Mice Carrying this Mutation:	70 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa4 Mutation: 9 strains or lines available

References

• Original: J:22077 Horan GS, et al., Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12644-8
• All: 4 reference(s)