Cbx2^tm1Cim
Targeted Allele Detail

Summary

• Symbol: Cbx2^tm1Cim
• Name: chromobox 2; targeted mutation 1, Centre d'Immunologie de Marseille Luminy
• MGI ID: MGI:1857631
• Synonyms: M33 -
• Gene: Cbx2 Location: Chr11:118913845-118922101 bp, + strand Genetic Position: Chr11, 83.33 cM
• Alliance: Cbx2^tm1Cim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38487
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1-4. RT-PCR analysis confirmed the absence of the transcript in homozygous mice. (J:38487)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cbx2 Mutation: 38 strains or lines available

References

• Original: J:38487 Core N, et al., Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development. 1997 Feb;124(3):721-9
• All: 9 reference(s)