Bmi1^tm1Brn
Targeted Allele Detail

Summary

• Symbol: Bmi1^tm1Brn
• Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Anton Berns
• MGI ID: MGI:1857632
• Synonyms: bmi-1-, Bmi1^-
• Gene: Bmi1 Location: Chr2:18681953-18691440 bp, + strand Genetic Position: Chr2, 12.9 cM
• Alliance: Bmi1^tm1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17712
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the ATG start codon, the zinc finger motif, and part of the helix-turn-helix motif were replaced either with a hygromycin-resistance cassette or one that conveyed neomycin-resistance. (J:17712)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	126 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bmi1^tm1Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bmi1 Mutation: 31 strains or lines available

References

• Original: J:17712 van der Lugt NM, et al., Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994 Apr 1;8(7):757-69
• All: 84 reference(s)