Gbx2^tm1.1Mrt
Targeted Allele Detail

Summary

• Symbol: Gbx2^tm1.1Mrt
• Name: gastrulation brain homeobox 2; targeted mutation 1.1, Gail R Martin
• MGI ID: MGI:1857634
• Synonyms: Gbx2-, Gbx2^deltahb
• Gene: Gbx2 Location: Chr1:89855684-89858898 bp, - strand Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
• Alliance: Gbx2^tm1.1Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance cassette and one loxP site were inserted into a BamH1 site in an intron; a second loxP site was inserted downstream of the stop codon. To obtain mice in which the floxed region of the gene was deleted, the authors crossed mice heterozygous for this mutation with mice that expressed Cre DNA recombinase in the egg or early embryo under control of promoter elements from the mouse Zp3 gene or human beta-actin gene, respectively. The resulting allele lacks the sequences encoding the homeobox. (J:42110, J:79431)

Expression

In Mice Carrying this Mutation:	133 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	42 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbx2 Mutation: 27 strains or lines available

References

• Original: J:42110 Wassarman KM, et al., Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug;124(15):2923-34
• All: 21 reference(s)