Hand2^tm1Dsr
Targeted Allele Detail

Summary

• Symbol: Hand2^tm1Dsr
• Name: heart and neural crest derivatives expressed 2; targeted mutation 1, Deepak Srivastava
• MGI ID: MGI:1857639
• Synonyms: dHAND^null
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40768
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced the entire gene. (J:40768)

Expression

In Mice Carrying this Mutation:	75 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:40768 Srivastava D, et al., Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet. 1997 Jun;16(2):154-60
• All: 25 reference(s)