Prrx1^tm1Tex
Targeted Allele Detail

Summary

• Symbol: Prrx1^tm1Tex
• Name: paired related homeobox 1; targeted mutation 1, University of Texas
• MGI ID: MGI:1857640
• Synonyms: Prx1^-, Prx1^LacZ, Prx-1^neo
• Gene: Prrx1 Location: Chr1:163072688-163141279 bp, - strand Genetic Position: Chr1, 70.53 cM
• Alliance: Prrx1^tm1Tex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25649
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette was inserted into the 5' region of the homeobox domain. RT-PCR analysis failed to detect gene specific transcript in homozygous mutant animals. (J:25649)

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	39 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prrx1 Mutation: 31 strains or lines available

References

• Original: J:25649 Martin JF, et al., The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev. 1995 May 15;9(10):1237-49
• All: 9 reference(s)