Prrx2^tm1Hubr
Targeted Allele Detail

Summary

• Symbol: Prrx2^tm1Hubr
• Name: paired related homeobox 2; targeted mutation 1, Hubrecht Institute
• MGI ID: MGI:1857641
• Synonyms: Prx2 -
• Gene: Prrx2 Location: Chr2:30735076-30771263 bp, + strand Genetic Position: Chr2, 21.74 cM
• Alliance: Prrx2^tm1Hubr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50488
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ/PGK-Hygro cassette was inserted just upstream of the homeobox domain, such that the lacZ encoding sequence is in-frame. The allele is expected to express the first 88 amino acids of the Prrx2 protein, fused to the Beta-gal protein, in a pattern identical to that of the Prrx2 gene. The absence of both the homeodomain and the aristaless domain make it unlikely that the protein retains any endogenous biochemical activity. (J:50488)

Expression

In Mice Carrying this Mutation:

50 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prrx2 Mutation: 11 strains or lines available

References

• Original: J:50488 ten Berge D, et al., Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs. Development. 1998 Oct;125(19):3831-42
• All: 3 reference(s)