Il7^tm1Dnax
Targeted Allele Detail

Summary

• Symbol: Il7^tm1Dnax
• Name: interleukin 7; targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
• MGI ID: MGI:1857652
• Synonyms: Il7-, IL-7-
• Gene: Il7 Location: Chr3:7637088-7678820 bp, - strand Genetic Position: Chr3, 2.02 cM
• Alliance: Il7^tm1Dnax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24165
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced all of exon 4 and 300 bp of flanking sequence. (J:24165)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il7 Mutation: 33 strains or lines available

References

• Original: J:24165 von Freeden-Jeffry U, et al., Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med. 1995 Apr 1;181(4):1519-26
• All: 103 reference(s)