Hgf^tm1Cbm
Targeted Allele Detail

Summary

• Symbol: Hgf^tm1Cbm
• Name: hepatocyte growth factor; targeted mutation 1, Carmen Birchmeier
• MGI ID: MGI:1857656
• Synonyms: SF/HGF^-
• Gene: Hgf Location: Chr5:16758493-16825150 bp, + strand Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
• Alliance: Hgf^tm1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23170
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of exon 2, which encodes amino acids 31 to 84 of the receptor binding domain, and replacement of these sequences with a neomycin cassette. (J:23170)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgf Mutation: 55 strains or lines available

References

• Original: J:23170 Schmidt C, et al., Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995 Feb 23;373(6516):699-702
• All: 5 reference(s)