Pitx1^tm1Jdr
Targeted Allele Detail

Summary

• Symbol: Pitx1^tm1Jdr
• Name: paired-like homeodomain transcription factor 1; targeted mutation 1, Jaques Drouin
• MGI ID: MGI:1857659
• Synonyms: Pitx^tm1, Ptx1-
• Gene: Pitx1 Location: Chr13:55972864-55984005 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Pitx1^tm1Jdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52671
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of this gene containing a homeodomain was replaced with a PGKneo-derived cassette via homologous recombination. Gene expression was not detected in Northern blot of mandibles from homozygous mutant embryos. (J:52671)

Expression

In Mice Carrying this Mutation:	76 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx1 Mutation: 11 strains or lines available

References

• Original: J:52671 Lanctot C, et al., Hindlimb patterning and mandible development require the Ptx1 gene. Development. 1999 May;126(9):1805-10
• All: 9 reference(s)