Lnpk^Ul
Radiation induced Allele Detail

Summary

• Symbol: Lnpk^Ul
• Name: lunapark, ER junction formation factor; ulnaless
• MGI ID: MGI:1857660
• Synonyms: Ul
• Gene: Lnpk Location: Chr2:74350635-74409779 bp, - strand Genetic Position: Chr2, 44.13 cM
• Alliance: Lnpk^Ul page

Lnpk^Ul/+

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (C3H/HeJ x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• Lnpk^Ul involves 22 genes/genome features (Lnpk, Mrpl23-ps1, Evx2 ...) View all
• Mutation details: The ulnaless mouse has been characterized as a paracentric inversion with a centromeric breakpoint into the lunapark gene and a telomeric breakpoint 770 kb away. This inversion disrupts the lunapark gene and increases the distance between the neighboring HoxD cluster and a cluster of enhancer sequences controlling several distinct genes over a large region. Genes Evx2, Hoxd12 and Hoxd13 are all misexpressed in the limb buds and genital buds of the ulnaless mouse. The inverted DNA includes Evx2, the HoxD complex, Mtx2, as well as some pseudogenes. (J:83372)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:

62 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lnpk Mutation: 28 strains or lines available

References

• Original: J:13461 Morris T, Ul. Mouse News Lett. 1967;36:34
• All: 9 reference(s)