Smad5^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Smad5^tm1Zuk
• Name: SMAD family member 5; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:1857666
• Synonyms: smad5^m1
• Gene: Smad5 Location: Chr13:56850823-56890190 bp, + strand Genetic Position: Chr13, 30.12 cM
• Alliance: Smad5^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53293
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hprt expression cassette replaced exon 2 and its flanking sequences. In addition, a transcriptional terminator sequence was introduced into intron 1. (J:53293)

Disease models

Expression

In Mice Carrying this Mutation:	148 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad5^tm1Zuk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad5 Mutation: 23 strains or lines available

References

• Original: J:53293 Chang H, et al., Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development. 1999 Apr;126(8):1631-42
• All: 14 reference(s)