Myog^tm1Whk
Targeted Allele Detail

Summary

• Symbol: Myog^tm1Whk
• Name: myogenin; targeted mutation 1, William H Klein
• MGI ID: MGI:1857667
• Synonyms: Myg^ml, Myog^-
• Gene: Myog Location: Chr1:134217742-134220286 bp, + strand Genetic Position: Chr1, 58.18 cM
• Alliance: Myog^tm1Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:14208
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the first exon of the Myog locus, at a site corresponding to 25 codons downstream of the initiator methionine codon. The mutation was shown to eliminate expression of the gene. (J:14208)

Expression

In Mice Carrying this Mutation:	154 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myog Mutation: 14 strains or lines available

References

• Original: J:14208 Hasty P, et al., Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene [see comments]. Nature. 1993 Aug 5;364(6437):501-6
• All: 15 reference(s)