Cdh5^tm1Hub
Targeted Allele Detail

Summary

• Symbol: Cdh5^tm1Hub
• Name: cadherin 5; targeted mutation 1, Philippe Huber
• MGI ID: MGI:1857669
• Synonyms: VE-cadherin^-
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^tm1Hub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54177
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 2, including sequences encoding the initiation codon, the signal peptide, the propeptide and the first 9 amino acids of the mature protein. (J:40971)

Expression

In Mice Carrying this Mutation:	67 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

References

• Original: J:54177 Gory-Faure S, et al., Role of vascular endothelial-cadherin in vascular morphogenesis. Development. 1999 May;126(10):2093-102
• All: 4 reference(s)