Tgfb1^tm1N
Targeted Allele Detail

Summary

• Symbol: Tgfb1^tm1N
• Name: transforming growth factor, beta 1; targeted mutation 1, National Institutes of Health
• MGI ID: MGI:1857671
• Synonyms: Tgfb1-, TGF-beta1-
• Gene: Tgfb1 Location: Chr7:25386427-25404502 bp, + strand Genetic Position: Chr7, 13.98 cM
• Alliance: Tgfb1^tm1N page

Histopathological analysis on lung and heart tissues of Tgfb1^tm1N/Tgfb1^tm1N mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50848
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the first exon and intron was replaced by a phosphoglycerate kinase-neomycin resistance gene. (J:18881, J:50848)

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfb1^tm1N

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfb1 Mutation: 35 strains or lines available

References

• Original: J:50848 Kulkarni AB, et al., Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4
• All: 73 reference(s)