Pax2^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Pax2^tm1Pgr
• Name: paired box 2; targeted mutation 1, Peter Gruss
• MGI ID: MGI:1857673
• Synonyms: Pax-2^-, Pax2^-
• Gene: Pax2 Location: Chr19:44744484-44826310 bp, + strand Genetic Position: Chr19, 38.09 cM
• Alliance: Pax2^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30343
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 4kb of sequence including the translation start site in exon 1, intron 1, and part of the paired box region of exon 2. (J:30343)

Disease models

Expression

In Mice Carrying this Mutation:	99 assay results
In Structures Affected by this Mutation:	46 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax2 Mutation: 44 strains or lines available

References

• Original: J:30343 Torres M, et al., Pax-2 controls multiple steps of urogenital development. Development. 1995 Dec;121(12):4057-65
• All: 18 reference(s)