Ctnnb1^tm1Max
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm1Max
• Name: catenin beta 1; targeted mutation 1, Max Planck Institut fur Immunbiologie
• MGI ID: MGI:1857678
• Synonyms: beta-cat -, beta-cateninⁿ, Catnb^tm1Kem
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm1Max page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29881
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-Betageo cassette replaced exon 2 and part of exon 3. Immunofluorescence studies using affinity purified anti-peptide antibodies detected only residual maternal Beta-catenin in homozygous mutant 5.5-day postcoitum expanded blastocysts. (J:29881)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

References

• Original: J:29881 Haegel H, et al., Lack of beta-catenin affects mouse development at gastrulation. Development. 1995 Nov;121(11):3529-37
• All: 11 reference(s)