Arnt^tm1Mcs
Targeted Allele Detail

Summary

• Symbol: Arnt^tm1Mcs
• Name: aryl hydrocarbon receptor nuclear translocator; targeted mutation 1, M Celeste Simon
• MGI ID: MGI:1857680
• Synonyms: Arnt(-), Arnt-
• Gene: Arnt Location: Chr3:95341699-95404551 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Arnt^tm1Mcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39730
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin resistance cassette was inserted into the exon that encodes the basic-helix-loop-helix domain. (J:39730)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arnt Mutation: 65 strains or lines available

References

• Original: J:39730 Maltepe E, et al., Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 1997 Mar 27;386(6623):403-7
• All: 7 reference(s)