Herc2^jdf2-8R
Chemically induced Allele Detail

Summary

• Symbol: Herc2^jdf2-8R
• Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2; juvenile development and fertility 2, 8 Oak Ridge
• MGI ID: MGI:1857687
• Synonyms: Herc2^8R, Herc2^jdf2-1971SJ, jdf2^1971SJ
• Gene: Herc2 Location: Chr7:55699944-55881548 bp, + strand Genetic Position: Chr7, 33.42 cM
• Alliance: Herc2^jdf2-8R page

Mutation origin

• Strain of Origin: BJR

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single A to G transition in a consensus 5 splice donor site results in the deletion of a 109 nucleotide exon and leads to a frameshift with a premature stop codon, allowing for only the first 2733 amino acids to be translated. (J:53404, J:56827)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Herc2 Mutation: 215 strains or lines available

References

• Original: J:56827 Walkowicz M, et al., Molecular characterization of radiation- and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice. Mamm Genome. 1999 Sep;10(9):870-8
• All: 3 reference(s)