Vcan^{Tg(Hoxa1)1Chm}
Transgenic Allele Detail

Summary

• Symbol: Vcan^{Tg(Hoxa1)1Chm}
• Name: versican; transgene insertion 1, Corey H Mjaatvedt
• MGI ID: MGI:1857689
• Synonyms: Cspg2^hdf, hdf, hdf, heart defect, Vcan^hdf
• Gene: Vcan Location: Chr13:89803431-89890628 bp, - strand Genetic Position: Chr13, 45.5 cM
• Alliance: Vcan^{Tg(Hoxa1)1Chm} page

Transgene origin

• Strain of Origin: C57BL/6J or CBA

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The transgene consisted of 3.5kb of the Hoxa1 regulatory region gene with a lacZ reporter sequence. The transgene inserted into intron 7 and separates exons 7 and 8, which code for the two chondroitin sulfate binding domains. RT-PCR analysis detected truncated mRNA transcripts in homozygous embryos. None of the alternative splice forms of the gene are detected in hearts from homozygous mice. (J:50233)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcan Mutation: 164 strains or lines available

References

• Original: J:41016 Yamamura H, et al., A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Dev Biol. 1997 Jun 1;186(1):58-72
• All: 16 reference(s)