Smad2^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1Rob
• Name: SMAD family member 2; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:1857691
• Synonyms: Smad2^-, Smad2^Robm1
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46532
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced the first coding exon of the gene. (J:46532)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad2^tm1Rob

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:46532 Waldrip WR, et al., Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell. 1998 Mar 20;92(6):797-808
• All: 13 reference(s)