About   Help   FAQ
Smad2tm1Cxd
Targeted Allele Detail
Summary
Symbol: Smad2tm1Cxd
Name: SMAD family member 2; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1857694
Synonyms: smad2deltaC
Gene: Smad2  Location: Chr18:76374651-76444034 bp, + strand  Genetic Position: Chr18, 51.42 cM
Alliance: Smad2tm1Cxd page
Morphological analysis of the Smad2tm1Cxd/Smad2tm1Cxd embryo

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49084
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced 2.5 kb of the gene, including the sequence that encodes the carboxy-terminal 86 amino acids of the protein. Southern blots and PCR analysis indicated that the mutation was passed on to the agouti offspring of the chimeras. (J:49084)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 56 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  52 strains or lines available
References
Original:  J:49084 Weinstein M, et al., Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9378-83
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory