Smad3^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Smad3^tm1Cxd
• Name: SMAD family member 3; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:1857695
• Synonyms: Smad3^-, Smad3^delEx8, Smad3^ex8
• Gene: Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
• Alliance: Smad3^tm1Cxd page

Skeletal defects in 7 month old Smad3^tm1Cxd/Smad3^tm1Cxd mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53510
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 8 of the gene, which truncated the protein 89 amino acids from the C-terminal end. (J:53510)

Disease models

Expression

In Mice Carrying this Mutation:	47 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	30 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad3^tm1Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad3 Mutation: 22 strains or lines available

References

• Original: J:53510 Yang X, et al., Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 1999 Mar 1;18(5):1280-91
• All: 145 reference(s)