Smad3^tm1Xfw
Targeted Allele Detail

Summary

• Symbol: Smad3^tm1Xfw
• Name: SMAD family member 3; targeted mutation 1, Xiao Fan Wang
• MGI ID: MGI:1857696
• Synonyms: Smad3^-, Smad3^null
• Gene: Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
• Alliance: Smad3^tm1Xfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53948
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first exon and part of the first intron, including the initiating ATG codon. (J:53948)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad3 Mutation: 22 strains or lines available

References

• Original: J:53948 Datto MB, et al., Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol. 1999 Apr;19(4):2495-504
• All: 30 reference(s)