Smad4^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1Mmt
• Name: SMAD family member 4; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:1857697
• Synonyms: Dpc4(-)
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46242
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 1 of the gene, truncating the peptide after 75 residues. (J:46242)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm1Mmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:46242 Takaku K, et al., Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell. 1998 Mar 6;92(5):645-56
• All: 14 reference(s)