Smad4^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1Cxd
• Name: SMAD family member 4; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:1857698
• Synonyms: S4^-, smad4-, Smad4^ex8
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1Cxd page

Morphological and molecular analyses of Smad4^tm1Cxd/Smad4^tm1Cxd embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46852
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 8 of the gene, which resulted in a 198 amino acid truncation of the protein's C-terminal end. (J:46852)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm1Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:46852 Yang X, et al., The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72
• All: 11 reference(s)