Smad5^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Smad5^tm1Cxd
• Name: SMAD family member 5; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:1857699
• Synonyms: Smad5^ex6/ex6
• Gene: Smad5 Location: Chr13:56850823-56890190 bp, + strand Genetic Position: Chr13, 30.12 cM
• Alliance: Smad5^tm1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53289
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 6 of the gene, causing truncation of the protein 179 amino acids from the C-terminal end. Northern analysis of RNA isolated from mutant embryos failed to show any transcript for the targeted gene. (J:53289)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad5 Mutation: 23 strains or lines available

References

• Original: J:53289 Yang X, et al., Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
• All: 3 reference(s)