Rac1^tm1Jms
Targeted Allele Detail

Summary

• Symbol: Rac1^tm1Jms
• Name: Rac family small GTPase 1; targeted mutation 1, Institute of Medical Science, Japan
• MGI ID: MGI:1857700
• Gene: Rac1 Location: Chr5:143491236-143513786 bp, - strand Genetic Position: Chr5, 82.22 cM
• Alliance: Rac1^tm1Jms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52224
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo-gpt cassette replaced a genomic fragment containing exons E1 and E2. These exons encode amino acids 97-192 of the protein. (J:52224)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rac1 Mutation: 24 strains or lines available

References

• Original: J:52224 Sugihara K, et al., Rac1 is required for the formation of three germ layers during gastrulation. Oncogene. 1998 Dec 31;17(26):3427-33
• All: 4 reference(s)