Wnt7a^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt7a^tm1Amc
• Name: wingless-type MMTV integration site family, member 7A; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1857704
• Synonyms: Wnt-7a
• Gene: Wnt7a Location: Chr6:91340963-91388335 bp, - strand Genetic Position: Chr6, 40.45 cM
• Alliance: Wnt7a^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23922
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 2. Authors state that this is likely a null allele, but present no molecular evidence. (J:23922)

Expression

In Mice Carrying this Mutation:	95 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt7a Mutation: 26 strains or lines available

References

• Original: J:23922 Parr BA, et al., Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature. 1995 Mar 23;374(6520):350-3
• All: 32 reference(s)