Acvr2b^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Acvr2b^tm1Enl
• Name: activin receptor IIB; targeted mutation 1, En Li
• MGI ID: MGI:1857709
• Synonyms: ActRIIB^-, Acvr2b-, IIB-KO
• Gene: Acvr2b Location: Chr9:119231184-119264061 bp, + strand Genetic Position: Chr9, 71.33 cM
• Alliance: Acvr2b^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42018
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.4kb genomic fragment containing two exons encoding the transmembrane and part of the kinase domains was replaced by a neomycin resistance cassette. (J:42018)

Disease models

Expression

In Mice Carrying this Mutation:	83 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr2b Mutation: 27 strains or lines available

References

• Original: J:42018 Oh SP, et al., The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 1997 Jul 15;11(14):1812-26
• All: 16 reference(s)