Acvr1b^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Acvr1b^tm1Enl
• Name: activin A receptor, type 1B; targeted mutation 1, En Li
• MGI ID: MGI:1857710
• Synonyms: ActRIB-
• Gene: Acvr1b Location: Chr15:101071953-101111565 bp, + strand Genetic Position: Chr15, 56.48 cM
• Alliance: Acvr1b^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46637
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into the exon encoding kinase subdomain VI. (J:46637)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1b Mutation: 37 strains or lines available

References

• Original: J:46637 Gu Z, et al., The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev. 1998 Mar 15;12(6):844-57
• All: 6 reference(s)