Acvr1^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Acvr1^tm1Enl
• Name: activin A receptor, type 1; targeted mutation 1, En Li
• MGI ID: MGI:1857711
• Synonyms: ActRIA^tm1
• Gene: Acvr1 Location: Chr2:58336450-58456840 bp, - strand Genetic Position: Chr2, 33.05 cM
• Alliance: Acvr1^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54394
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 4, which encodes the transmembrane domain. Alternative splicing that skips the disrupted exon is predicted to cause a frame shift in the kinase domain. (J:54394)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1 Mutation: 44 strains or lines available

References

• Original: J:54394 Gu Z, et al., The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development. 1999 Jun;126(11):2551-61
• All: 4 reference(s)