Flt1^tm1Jrt
Targeted Allele Detail

Summary

• Symbol: Flt1^tm1Jrt
• Name: FMS-like tyrosine kinase 1; targeted mutation 1, Janet Rossant
• MGI ID: MGI:1857717
• Synonyms: Flt-1^-, Flt-1^lacZ, Flt1^lacZ, flt-1^lcz, VEGFR1-lacZ
• Gene: Flt1 Location: Chr5:147498414-147662821 bp, - strand Genetic Position: Chr5, 87.01 cM, cytoband G
• Alliance: Flt1^tm1Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ-neomycin resistance cassette replaced sequences that encode the signal peptide. The authors predict this is a null allele because the translation start site is removed and reinitiation at the first two downstream Kozak sequences would result in out-of-frame translated products. (J:26845)

Expression

In Mice Carrying this Mutation:	103 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flt1 Mutation: 76 strains or lines available

References

• Original: J:26845 Fong GH, et al., Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995 Jul 6;376(6535):66-70
• All: 34 reference(s)