Hif1a^tm1Jhu
Targeted Allele Detail

Summary

• Symbol: Hif1a^tm1Jhu
• Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Johns Hopkins University
• MGI ID: MGI:1857719
• Synonyms: Hif1a^-
• Gene: Hif1a Location: Chr12:73948186-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
• Alliance: Hif1a^tm1Jhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45554
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exon 2, which encodes the bHLH domain, of the gene. (J:45554)

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hif1a Mutation: 50 strains or lines available

References

• Original: J:45554 Iyer NV, et al., Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998 Jan 15;12(2):149-62
• All: 33 reference(s)