Lig4^tm1Icrf
Targeted Allele Detail

Summary

• Symbol: Lig4^tm1Icrf
• Name: ligase IV, DNA, ATP-dependent; targeted mutation 1, Imperial Cancer Research Fund
• MGI ID: MGI:1857720
• Synonyms: lig4-
• Gene: Lig4 Location: Chr8:10020020-10027680 bp, - strand Genetic Position: Chr8, 4.52 cM
• Alliance: Lig4^tm1Icrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51608
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the DNA sequence encoding amino acids 142 - 685 of the protein. (J:51608)

Disease models

Expression

In Mice Carrying this Mutation:

8 assay results

Tumor Data

List all tumor models in MMHCdb carrying Lig4^tm1Icrf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lig4 Mutation: 46 strains or lines available

Notes

ES cell line = GK129 (129P2/OlaHsd) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺).

References

• Original: J:51608 Barnes DE, et al., Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol. 1998 Dec 17-31;8(25):1395-8
• All: 9 reference(s)