Htt^tm1Szi
Targeted Allele Detail

Summary

• Symbol: Htt^tm1Szi
• Name: huntingtin; targeted mutation 1, Scott Zeitlin
• MGI ID: MGI:1857722
• Synonyms: Hdh-, Hdh^prex1
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm1Szi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29267
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 2.8 kb fragment of the gene, which included the 5' flanking sequence, the entire first exon, and 0.6 kb of the 3' flanking intron. (J:29267)

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 178 strains or lines available

References

• Original: J:29267 Zeitlin S, et al., Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet. 1995 Oct;11(2):155-63
• All: 15 reference(s)