Foxa2^tm1Jrt
Targeted Allele Detail

Summary

• Symbol: Foxa2^tm1Jrt
• Name: forkhead box A2; targeted mutation 1, Janet Rossant
• MGI ID: MGI:1857725
• Synonyms: Foxa2^-, Foxa2^null, HNF-3beta-, HNF3Beta, HNF3Beta^-, HNF-3beta^tm1Jrt, Hnf3b^tm1Jrt
• Gene: Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
• Alliance: Foxa2^tm1Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19895
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The entire coding sequence of the gene was replaced with a neomycin selection cassette. (J:19895, J:47841)

Expression

In Mice Carrying this Mutation:	172 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Foxa2 Mutation: 28 strains or lines available

Notes

Double null mutants for this allele and Gsc^tm1Bhr are altered in phenotype by embryonic day 8.75, with loss of Shh (sonic hedgehog) expression as well as that of Foxa2 in the notochord and ventral neural tube. In the forebrain, loss of expression of the fibroblast growth factor gene Fgf8 may also occur (J:41809).

References

• Original: J:19895 Ang SL, et al., HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
• All: 20 reference(s)