Tlr4^lps-n
Spontaneous Allele Detail

Summary

• Symbol: Tlr4^lps-n
• Name: toll-like receptor 4; normal lipopolysaccharide response
• MGI ID: MGI:1857731
• Synonyms: TLR⁺, TLR4^s
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^lps-n page

Mutation origin

• Strain of Origin: C3H/HeN

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: The allele for normal response to lipopolysaccharides, Lpsⁿ, occurs in most C3H substrains and in other inbred strains. (J:51522)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

Notes

A/J, C3H/HeN, and C3H/HePas mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4^lps-n allele; others, including Tlr4^Lps-d, show codominance.

References

• Original: J:5721 Dumont F, et al., Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha). 1976;12(3):145-50
• All: 37 reference(s)