Lig4^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Lig4^tm1Fwa
• Name: ligase IV, DNA, ATP-dependent; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:1857732
• Synonyms: Lig4^-, LigIV^-
• Gene: Lig4 Location: Chr8:10020020-10027680 bp, - strand Genetic Position: Chr8, 4.52 cM
• Alliance: Lig4^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50865
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced more than 50% of the coding sequences for the gene, removing the nucleotide sequences that encode amino acids 143 - 608 of the protein. (J:50865)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lig4^tm1Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lig4 Mutation: 46 strains or lines available

References

• Original: J:50865 Frank KM, et al., Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998 Nov 12;396(6707):173-7
• All: 32 reference(s)