Chuk^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Chuk^tm1Aki
• Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:1857735
• Synonyms: IKKalpha^-
• Gene: Chuk Location: Chr19:44061774-44095919 bp, - strand Genetic Position: Chr19, 36.71 cM
• Alliance: Chuk^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54315
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced an exon encoding subdomain VI of the kinase catalytic domain. Northern and western blot analysis of embryonic fibroblast cells derived from homozygous mice confirmed that expression of the mRNA and protein was abolished. (J:54315)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chuk Mutation: 51 strains or lines available

References

• Original: J:54315 Takeda K, et al., Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science. 1999 Apr 9;284(5412):313-6
• All: 13 reference(s)